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App Note: AN6 Sample-prep-free extracellular vesicle isolation in biological samples
Efficient quantification and isolation of extracellular vesicles with a fast and sensitive dip-in assay WHITE FOx can directly isolate tissue marker-specific extracellular vesicles (EVs) from minimal quantities of blood plasma...
July 10, 2024
App Note: AN5 Want to detect extracellular vesicles directly in complex samples?
Sensitive and efficient detection of extracellular vesicles using a fast dip-in assay with minimal hands-on time WHITE FOx streamlines the detection and quantification of extracellular vesicles (EVs) in highly heterogeneous...
App Note: AN4 How to select your best performing single domain antibodies
A fast, dip-in assay can provide comprehensive kinetic analysis to determine the most appropriate binding proteins Single domain antibodies (sdAbs) have an improved capacity to penetrate tissues, making them powerful...
May 14, 2024
App Note: AN3 Improve your biopanning selection process with real-time monitoring
More efficient biotherapeutic discovery and screening using a fast, dip-in assay WHITE FOx can measure the real-time concentration of phage clones through multiple cycles of selection. The dipin sensor configuration...
App Note: AN2 Can you get immediate kinetic characterization from phage display clones?
More efficient biotherapeutic discovery and screening using a fast, dip-in assay WHITE FOx can measure the kinetics of phage clones to provide insights into their affinity and avidity, providing a...
App Note: AN1 Looking for a faster way to monitor biotherapeutics yield from cell culture?
More efficient drug discovery and R&D using a dip-in assay WHITE FOx can be used on crude samples, including cell culture media, and could be invaluable as an analysis tool...
White paper: WP10 Kinetic analysis of VHH and antibodies with WHITE FOx
White paper 10 | Version 1 | Tobias Zbik, Sarah Parmentier, Kris Ver Donck ABSTRACT The landscape of antibody research continuously evolves, with novel antibody variants such as VHH, antibody-drug...
April 23, 2024
Development and validation of an optical biosensor for rapid monitoring of adalimumab in serum of patients with Crohn’s disease
Bian et al. (2017) RPTH 7, doi: 10.1002/dta.2250 Therapeutic drug monitoring of adalimumab is recommended to improve therapeutic outcome in patients with Crohn’s disease. Performing an ELISA requires a rather…
January 29, 2024
White paper: WP9 Isolation of neuron-specific extracellular vesicles from human plasma using FO-SPR
White paper 9 | Version 2 | Tobias Zbik, Filip Delport SUMMARY Extracellular vesicles (EVs) are an increasingly popular target in the search for novel biomarkers in the field of...
January 25, 2024
White paper: WP8 Affinity determination of single domain antibodies for detection of biomarkers
White paper 8 | Version 2 | Laura Marin, Sarah Parmentier, Kris Ver Donck, Filip Delport SUMMARY Single domain antibodies (sdAbs) and adhirons are an alternative to conventional antibodies for...
November 20, 2023
Measuring ADAMTS-13 activity to diagnose thrombotic thrombocytopenic purpura: a novel, fast fiber-optic surface plasmon resonance immunoassay
Bonnez et al. (2023) RPTH 7, DOI: 10.1016/j.rpth.2023.102171 Thrombotic thrombocytopenic purpura (TTP) is characterized by severe ADAMTS-13 activity deficiency (<10%). Diagnostic testing is challenging because of unavailability, high cost, and…
September 27, 2023
White paper: WP7 Versatile and fast IgG screening with the Protein A sensor probe
White paper 7 | Version 2 | Kris Ver Donck, Filip Delport, Laura Marin, Emma Buchet, Kim Stevens SUMMARY FOx BIOSYSTEMS’ fiber-optic surface plasmon resonance technology (FO-SPR) is a robust...
March 20, 2023
Integrated Signal Amplification on a Fiber Optic SPR Sensor Using Duplexed Aptamers
Dillen et al. (2023) ACS Sensors DOI: 10.1021/acssensors.2c02388 Throughout the past decades, fiber optic surface plasmon resonance (FO-SPR)-based biosensors have proven to be powerful tools for both the characterization of…
February 16, 2023
Detection of Breast Cancer-Specific Extracellular Vesicles with Fiber-Optic SPR Biosensor
Yildizhan et al. (2023) International Journal of Molecular Sciences DOI: 10.3390/ijms24043764 Extracellular vesicles (EVs) have attracted great attention as potential biomarkers for cancer diagnostics. Although several technologies have been developed…
February 15, 2023
Immunogenic affinity and extracellular vesicle quantification in blood with FO-SPR
June 20-22, 2022 – MOSBRI Scientific Conference Our CTO, Dr. Filip Delport, had the opportunity to present at the 1st MOSBRI Scientific Conference in June 2022. He explained how the…
December 8, 2022
New technology for the development of molecular markers
Georg Johnen, Thomas Brüning, IPA (Institut für Prävention und Arbeitsmedizin der Deutschen Gesetzlichen Unfallversicherung) The detection of specific proteins is the focus of many methods for the diagnosis of occupational…
December 7, 2022
White paper: WP6 Using FO-SPR to select for nanobodies in phage display
White paper 6 | Version 2 | Kris Ver Donck, Dagmara Minczakiewicz, Filip Delport, Kim Stevens Based on original publication: Knez et al. (2013) Analytical Chemistry 85, 10075 - 10082...
April 29, 2022
Innovative FO-SPR Label-free Strategy for Detecting Anti-RBD Antibodies in COVID-19 Patient Serum and Whole Blood
Qu et al. (2022) ACS Sensors DOI: 10.1021/acssensors.1c02215 The ongoing COVID-19 pandemic has emphasized the urgent need for rapid, accurate, and large-scale diagnostic tools. Next to this, the significance of…
January 27, 2022
White paper: WP5 Extracellular vesicle quantification in complex matrices
White paper 5 | Version 2 | Kris Ver Donck, Filip Delport, Kim Stevens Based on original publication: Yildizhan et al. (2021) Journal of Extracellular Vesicles. 10 (4) ABSTRACT Fiber-optic...
December 15, 2021
White paper: WP4 Label-free quantification in bioproduction samples
White paper 4 | Version 4 | Kris Ver Donck², Dagmara Minczakiewicz², Kim Stevens², Gert Struys¹, Thomas Geuens¹, Koen Dierckx¹, Filip Delport² ¹simAbs NV, ²FOx BIOSYSTEMS ABSTRACT This white paper...
October 1, 2021
Gold nanoparticle enhanced multiplexed biosensing on a fiber optic surface plasmon resonance probe
Qu et al. (2021) Biosensors and Bioelectronics 192, 113549 We present an innovative multiplexing concept on a fiber optic surface plasmon resonance (FO-SPR) platform and demonstrate for the first time…
August 24, 2021
White paper: WP3 Sensitive protein quantification in whole blood, dried blood spots, serum and plasma
White paper 3 | Version 2 | Kim Stevens, Kris Ver Donck, Filip Delport Based on original publication: Lu et al. (2017) Analytical Chemistry 89, 3664-3671. (1) ABSTRACT Fiber-optic surface...
June 29, 2021
White paper: WP2 sensitive protein quantification in serum – comparison of FO-SPR and ELISA
White paper 2 | Kim Stevens, Kris Ver Donck, Filip Delport Based on original publication: Lu et al. (2016) Biosensors and Bioelectronics 79, 173–179. (1) ABSTRACT This white paper demonstrates...
April 23, 2021
WHITE FOxTM technical specifications
You can find the technical specifications of the White FOxTM here: DOWNLOAD
April 8, 2021
White paper: WP1 carboxyl probe immobilization for label-free protein quantification
White paper 1 | Filip Delport, Dagmara Minczakiewicz, Kris Ver Donck ABSTRACT This white paper describes a general strategy for optimizing immobilization on the FO-SPR probes and provides some reference...
March 31, 2021
FO-SPR biosensor calibrated with recombinant extracellular vesicles enables specific and sensitive detection directly in complex matrices
Yilidzhan et al. (2021) J. Extracell. Vesicles 10 Extracellular vesicles (EVs) have drawn huge attention for diagnosing myriad of diseases, including cancer. However, the EV detection and analyses procedures…
February 23, 2021
Real-time FO-SPR monitoring of solid-phase DNAzyme cleavage activity for cutting-edge biosensing
Peeters et al. (2019) ACS Appl. Mater. Interfaces 11, 7, 6759–6768 DNA nanotechnology has a great potential in biosensor design including nanostructuring of the biosensor surface through DNA origami,…
January 25, 2019
Immunoassay for detection of infliximab in whole blood using a fiber-optic surface plasmon resonance biosensor
Lu et al. (2017) Anal. Chem. 89, 3664−3671 Monitoring the concentration of a therapeutic drug antibody, infliximab (IFX), is recommended for enhancing its efficacy in patients with inflammatory bowel…
February 22, 2017
Competitive inhibition assay for the detection of progesterone in dairy milk using a fiber optic SPR biosensor
Daems et al. (2017) Analytica Chimica Acta 950, 1e6 Analytical methods that are often used for the quantification of progesterone in bovine milk include immunoassays and chromatographic techniques. Depending on the selected method,…
January 15, 2017
Fiber optic-SPR platform for fast and sensitive infliximab detection in serum of inflammatory bowel disease patients
Lu et al. (2016) Biosensors and Bioelectronics 79, 173–179 Infliximab (IFX) is a therapeutic monoclonal antibody used for treating patients with inflammatory bowel disease (IBD). In order to improve…
May 15, 2016
Real-time ligation chain reaction for DNA quantification and identification on the FO-SPR
Knez et al. (2015) Biosensors and Bioelectronics 65, 394-399 Different assays have been developed in the past years to meet point-of-care diagnostic tests requirements for fast and sensitive quantification…
May 15, 2015
Probing the force-induced dissociation of aptamer-protein complexes
Perez-Ruiz et al. (2014) Anal. Chem. 86, 3084−3091 Aptamers are emerging as powerful synthetic bioreceptors for fundamental research, diagnostics, and therapeutics. For further advances, it is important to gain…
February 20, 2014
Affinity comparison of p3 and p8 peptide displaying bacteriophages using surface plasmon resonance
Knez et al. (2013) Anal. Chem. 85, 10075−10082 Ever increasing demands in sensitivity and specificity of biosensors have recently established a trend toward the use of multivalent bioreceptors. This…
September 30, 2013
Selection of aptamers against Ara h 1 protein for FO-SPR biosensing of peanut allergens in food matrices
Tran et al. (2013) Biosensors and Bioelectronics 43, 245–251 The rising prevalence to food allergies in the past two decades, together with the fact that the only existing therapy…
May 15, 2013
Fast and accurate peanut allergen detection with nanobead enhanced optical fiber SPR biosensor
Pollet et al. (2011) Talanta 83, 1436–1441 This paper is the first report of a fiber optic SPR biosensor with nanobead signal enhancement. We evaluated the system with a…
February 15, 2011
Fiber optic SPR biosensing of DNA hybridization and DNA–protein interactions
Pollet et al. (2009) Biosensors and Bioelectronics 25, 864–869 In this paper we present a fiber optic surface plasmon resonance (SPR) sensor as a reusable, cost-effective and label free biosensor for measuring DNA hybridization and DNA–protein…
December 15, 2009
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