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Fiber-optic surface plasmon resonance (FO-SPR) is a versatile technology that can be adapted for use in a wide variety of additional applications.

Our interchangeable probes are available with four surface chemistries, allowing you to select the most appropriate method for your bioassay.

A generic surface chemistry that serves a wide range of applications
For immobilized His-tag proteins; convenient for nanobodies and recombinant proteins and ideal for display library screening; allows multiplexing
For easy immobilization of biotin-labelled proteins, antibodies or peptides
Protein A
A generic surface for quantifying IgG; ideal for screening IgG libraries for binding potency

This combination of probes allows the quantification of proteins, small molecules, DNA or cells in microliter volumes, as well as a wide range of interaction analyses.

Furthermore, the fluidics-free setup also eliminates the clogging associated with microfluidics-based alternatives, thereby reducing sample processing steps.

Some of the other exciting things scientists are using our technology for:

  • Biologics production
    • Nanobody- or antibody-antigen kinetic affinity
    • Cellular bioreactor development
    • In-line process control systems
    • Analyzing antibody levels and binding kinetics in patient blood
  • Extracellular vesicle (EV) characterization
  • Fast sandwich assays using gold nanoparticles
  • Potency / denaturation assays
  • DNA / RNA
    • Quantification
    • Hybridization
    • And more
  • Allergen testing in food
    • Peanut
    • Progesterone in dairy milk
  • A wide range of interaction analyses, including potency assays, enzymatic lysis, etc.

The FO-SPR probes can be coupled with a range of compoundsMake use of the flexibility provided by interchangeable probes with different surfaces chemistries.

Relevant publications

Found 7 Results
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Integrated Signal Amplification on a Fiber Optic SPR Sensor Using Duplexed Aptamers

Dillen et al. (2023) ACS Sensors DOI: 10.1021/acssensors.2c02388 Throughout the past decades, fiber optic surface plasmon resonance (FO-SPR)-based biosensors have proven to be powerful tools for both the characterization of…

February 16, 2023

Real-time FO-SPR monitoring of solid-phase DNAzyme cleavage activity for cutting-edge biosensing

Peeters et al. (2019) ACS Appl. Mater. Interfaces 11, 7, 6759–6768   DNA nanotechnology has a great potential in biosensor design including nanostructuring of the biosensor surface through DNA origami,…

January 25, 2019

Competitive inhibition assay for the detection of progesterone in dairy milk using a fiber optic SPR biosensor

Daems et al. (2017) Analytica Chimica Acta 950, 1e6   Analytical methods that are often used for the quantification of progesterone in bovine milk include immunoassays and chromatographic techniques. Depending on the selected method,…

January 15, 2017

Real-time ligation chain reaction for DNA quantification and identification on the FO-SPR

Knez et al. (2015) Biosensors and Bioelectronics 65, 394-399   Different assays have been developed in the past years to meet point-of-care diagnostic tests requirements for fast and sensitive quantification…

May 15, 2015

Probing the force-induced dissociation of aptamer-protein complexes

Perez-Ruiz et al. (2014) Anal. Chem. 86, 3084−3091   Aptamers are emerging as powerful synthetic bioreceptors for fundamental research, diagnostics, and therapeutics. For further advances, it is important to gain…

February 20, 2014

Selection of aptamers against Ara h 1 protein for FO-SPR biosensing of peanut allergens in food matrices

Tran et al. (2013) Biosensors and Bioelectronics 43, 245–251    The rising prevalence to food allergies in the past two decades, together with the fact that the only existing therapy…

May 15, 2013

Fiber optic SPR biosensing of DNA hybridization and DNA–protein interactions

Pollet et al. (2009) Biosensors and Bioelectronics 25, 864–869   In this paper we present a fiber optic surface plasmon resonance (SPR) sensor as a reusable, cost-effective and label free biosensor for measuring DNA hybridization and DNA–protein…

December 15, 2009

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For Research Use Only. Not for use in diagnostic procedures.