WHITE FOx’s dip-in fiber-optic probes can be customized for a wide range of bioreceptors. Now available with four surface chemistries for greater convenience.

Our customizable, interchangeable probes consist of a gold-coated, optical fiber with a choice of four different surface chemistries that allow the binding of a range of proteins and biologics. These disposable probes are placed in WHITE FOx, a high-end, semi-automated analytical benchtop instrument for real-time analysis of biomolecular interactions.

This sensor technology uses the fiber-optic surface plasmon resonance (FO-SPR) principle for both labelled and label-free detection of biomolecules, including proteins, antibodies, nanobodies, phage, complex particles, microvesicles, or cells in microliter volumes.

Within a few minutes, you can get accurate information on binding affinity, kinetics or target concentration.

These interchangeable probes come in four different formats meaning that WHITE FOx can detect different target molecules with a single device, giving you full flexibility in use.

human IgG(1) concentration series from 0; 0.03 to 256 µg/ml, captured on a Protein A probe, over >45 cycles of regeneration.

Regeneration

All probes are compatible to common regeneration conditions. While regeneration on carboxyl and streptavidin probes may be limited by the stability of the capture proteins immobilised in the assay, the NTA and protein A probes allow for complete regeneration to return to the original probe surface. As these surfaces are robust, many regeneration cycles are possible.

In fast IgG quantification, more than 45 cycles of regeneration have shown to still produce complete recovery of probe sensitivity. So you can screen efficiently and reliably across an entire assay plate.