Light is totally reflected inside the optical fiber until it reaches the sensing zone which is gold coated and inserted into the sample. At the interface of the optical fiber – gold – liquid sample the incident light creates a resonant oscillation of plasmons. This causes a reduction in the intensity of light reflected inside the fiber where the resonance condition, or wavelength at which the least light is reflected, which is used to determine the mass of (bio)molecules in the sample closely surrounding the sensor surface.
FOx BIOSYSTEMS uses fiber-optic dip-in sensing for biomolecular interaction analyses
Applying state of the art surface chemistry allows coupling bioreceptors (e.g. antibodies) on the gold layer for specific and sensitive detection while suppressing nonspecific interactions. As the target molecules bind to the sensor surface and replace the surrounding matrix, a change in mass density is detected in real time by monitoring the change in wavelength of the resonance condition. This change can be tracked over time.
WHITE FOx provides top notch biomolecule interaction analysis, but so much easier to use with dip-in reading: at your bench, only standard assay expertise required, and opens up a whole world op samples not available to microfluidic analysis techniques.