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App Note: AN5 Want to detect extracellular vesicles directly in complex samples?

By July 10, 2024No Comments

Sensitive and efficient detection of extracellular vesicles using a fast dip-in assay with minimal hands-on time

WHITE FOx streamlines the detection and quantification of extracellular vesicles (EVs) in highly heterogeneous biofluids like blood plasma or culture medium, removing the need for prior purification. This simplified but highly sensitive approach could be invaluable for biomarker or cell and gene therapy studies by shortening the time from sample to result.

As an example, WHITE FOx’s dip-in sensors can be functionalized with EV-specific capture antibodies for label-free or sandwich bioassays to detect recombinant EVs (rEVs), endogenous EVs, and breast-cancer-derived EVs in complex cellular mixtures.